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মঙ্গলবার, ১৮ মার্চ ২০২৫, ০৮:০১ অপরাহ্ন

Synthroid Uses, Dosage & Side Effects

রিপোর্টার
  • আপডেট : মঙ্গলবার, ৪ মার্চ, ২০২৫

Synthroid Uses, Dosage & Side Effects

In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestationsof toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

  • Protein-bound thyroid hormones exist in reverse equilibrium with small amounts of free hormone.
  • A total of 153,775 patients (34,828 in the Synthroid cohort and 118,947 in the GL cohort) were initially identified for potential study inclusion (Fig. 1).
  • Children can take the medicine if the tablet is crushed and put into about 1 to 2 teaspoons of water; do not store or delay giving this crushed pill suspension.
  • Synthroid is a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body’s energy and metabolism.
  • The higher affinity of both TBG and TBPA for T4 partially explains the higher serum levels, slower metabolic clearance, and longer half-life of T4 compared to T3.

Patient Characteristics

  • Administration of sertraline in patients stabilized on SYNTHROID may result in increased SYNTHROID requirements.
  • Use the serum free-T4 level to titrate SYNTHROID dosing until the patient is clinically euthyroid and the serum free-T4 level is restored to the upper half of the normal range see Dosage and Administration (2.3).
  • Get medical help right away, if you have any of the symptoms listed above.
  • Secondary outcomes were measured in a subset of matched patients from the primary objective with complete pharmacy cost capture.
  • Patients were also required to have two or more fills for either Synthroid or GL (same or multiple).

James V. Hennessey is affiliated with Beth Israel Deaconess Medical Center, Boston, MA, and was under contract with AbbVie, Inc., to provide consulting services to the study. MG, BN, LW contributed to the design of the study; collected, analyzed, and interpreted the data; and drafted the manuscript. AB, RE, YC, JH contributed to the design of the study; interpreted the data; and provided critical revisions of the manuscript. Researchers only accessed data in the format of a limited data set for which a data use agreement was in place with the covered entities in compliance with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule. An Institutional Review Board did not review the study since only this limited data set was accessed.

Our Synthroid Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Notify your doctor if you experience serious side effects of Synthroid including rapid heartbeat, fluttering in your chest, or chest pain. Biochemical assessment incorporated measurement of serum TSH, T3, and T4. TSH lower limit of quantification was 0.2 mIU/L and upper limit of normal was 5.6 mIU/L, as indicated by the shaded area.

1 General Administration Information

Consider changes in TBG concentration when interpreting T4 and T3 values. Measure and evaluate unbound (free) hormone and/or determine the free-T4 index (FT4I) in this circumstance. Pregnancy, infectious hepatitis, estrogens, estrogen-containing oral contraceptives, and acute intermittent porphyria increase TBG concentration. Nephrosis, severe hypoproteinemia, severe liver disease, acromegaly, androgens, and corticosteroids decrease TBG concentration.

Levothyroxine monotherapy (Synthroid® or multiple generic levothyroxine GL formulations) is standard treatment for hypothyroidism. Our objective was to compare effectiveness (as measured by achievement of thyroid-stimulating hormone TSH levels) and economic outcomes of Synthroid vs. any one of multiple GLs in patients with hypothyroidism. Rapid restoration of normal serum T4 concentrations is essential for preventing the adverse effects of congenital hypothyroidism on cognitive development as well as on overall physical growth and maturation. Therefore, initiate SYNTHROID therapy immediately upon diagnosis. Levothyroxine is generally continued for life in these patients see WARNINGS AND PRECAUTIONS. Levothyroxine is generally continued for life in these patients see Warnings and Precautions (5.1).

Related treatment guides

Carefully monitor glycemic control, especially when thyroid therapy is started, changed, or discontinued see Warnings and Precautions (5.5). Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with SYNTHROID see Contraindications (4). SYNTHROID is indicated in adult and pediatric patients, including neonates, as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer. Titrate the dose of SYNTHROID carefully and monitor response to titration to avoid these effects see DOSAGE AND ADMINISTRATION. Consider the potential for food or drug interactions and adjust the administration or dosage of SYNTHROID as needed see DOSAGE AND ADMINISTRATION, DRUG INTERACTIONS and CLINICAL PHARMACOLOGY.

SYNTHROID® (levothyroxine sodium) tablets, for oral use is a prescription, man-made thyroid hormone that is used to treat a condition called hypothyroidism in adults and children, including infants. It is meant to replace a hormone that is usually made by your thyroid gland. Generally, thyroid replacement treatment is to be taken for life. SYNTHROID should not be used to treat noncancerous growths or enlargement of the thyroid in patients with normal iodine levels, or in cases of temporary hypothyroidism caused by inflammation of the thyroid gland (thyroiditis). With few exceptions, all-cause and hypothyroidism-related HCRU was comparable between the Synthroid and GL cohorts, most notably in terms of hospitalizations, outpatient services, and ED visits. Whereas no significant difference between the two groups in all-cause pharmacy fills was observed, the Synthroid cohort had significantly more hypothyroidism-related prescription fills per patient than the GL cohort.

Get medical help right away, if you have any of the symptoms listed above. Note that this list is not all-inclusive and includes only common medications that may interact with Synthroid. You should refer to the prescribing information for Synthroid for a complete list of interactions. It is essential to tell your doctor if you’re pregnant or plan on becoming pregnant.

By continuing to take Synthroid as your doctor prescribed and getting your levels checked regularly, you can help keep your thyroid hormone levels where they should be. The “optimal dose” was determined for each patient as that dosage of thyroxine being taken when the thyrotropin-releasing hormone (TRH) response was normal (ie, an increase in TSH of between 4.7 and 25 mIU/L). The signs and symptoms of overdosage are those of hyperthyroidism see Warnings and Precautions (5) and Adverse Reactions (6). Seizures occurred in a 3-year-old child ingesting 3.6 mg of levothyroxine. Since postpartum TSH levels are similar to preconception values, the SYNTHROID dosage should return to the pre-pregnancy dose immediately after delivery see Dosage and Administration (2.3). Monitor for cardiac arrhythmias during surgical procedures in patients with coronary artery disease receiving suppressive SYNTHROID therapy.

Drug Label Info

Many drugs and physiologic conditions affect the binding of thyroid hormones to serum proteins see Drug Interactions (7). Thyroid hormones do not readily cross the placental barrier see naproxen synthroid Use in Specific Populations (8.1). Published studies report that levothyroxine is present in human milk following the administration of oral levothyroxine.

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